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- Original Article Effects of Chromium Exposure on the Level of Urinary 8-Hydroxydeoxyguanosine
- Seong Joon Kim, Byung Chul Yu, Sang Hwa Ohm, Ki Won Jeong, Luck Hee Sung, Won Chang Shin, Jong Rae Cho, Jin Ho Chun
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Korean Journal of Occupational and Environmental Medicine (대한직업환경의학회지) 2001;13(3):253.
DOI: https://doi.org/10.35371/kjoem.2001.13.3.253
Published online: September 30, 2001
1Department of Preventive Medicine, Inje University, Korea. pmksj@snanggyepaik.or.kr 
2Department of Urology, Sanggye Paik Hospital, Korea.
3Department of Internal Medicine, Sanggye Paik Hospital, Korea.
4Department of Clinical Pathology, Ilsan Paik Hospital, Korea.
2Department of Urology, Sanggye Paik Hospital, Korea.
3Department of Internal Medicine, Sanggye Paik Hospital, Korea.
4Department of Clinical Pathology, Ilsan Paik Hospital, Korea.
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Abstract
OBJECTIVES
To investigate the possibility of utilizing DNA adduct as a carcinogenic biological marker for workers exposed to chromium, and the effect of chromium exposure on the formation of urinary 8-hydroxydeoxyguanosine(8-OH-dG) was also evaluated.
METHODS
The chromium concentrations of venous blood and urine were measured in 20 chromium exposed workers(exposure group) and in 11 chromium workers(control group) who were not exposed. The concentration of 8-OH-dG in their urine was determined using high performance liquid chromatography with electrochemical detection.
RESULTS
The blood chromium concentration was significantly higher in the exposure group ( 0.46+/-0.18 microgram/100 ml) than in control group(0.27+/-0.15 microgram/100 ml), but the urinary chromium concentration was not significantly higher in the exposure group. The urinary 8-OH-dG was higher in the exposure group(1.71+/-1.82 micromol/mol creatinine) than that in the control group(0.45+/-0.46 micromol/mol creatinine) and was significantly correlated with the blood chromium concentration(r=0.49). Results of multiple regression analysis revealed that the level of urinary 8-OH-dG depended upon the level of the blood chromium conc entration ( r2= 0.21).
CONCLUSIONS
Urinary 8-OH-dG was significantly related to chromium exposure and this finding suggests the possibility that urinary 8-OH-dG could be used as a biological index of chromium induced DNA damage.
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