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Original Article
- Relationship between crustacean consumption and serum perfluoroalkyl substances (PFAS): the Korean National Environmental Health Survey (KoNEHS) cycle 4
- Sung Woo Huh, Seong-yong Cho, Seongyong Yoon, Daehwan Kim, Hyun Woo Park, Jisoo Kang, Keon Woo Kim
- Ann Occup Environ Med 2024;36:e12. Published online April 19, 2024
- DOI: https://doi.org/10.35371/aoem.2024.36.e12
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Abstract
Abstract in Korean
PDF Background Perfluoroalkyl substances (PFASs) are non-aromatic organic compounds, whose hydrogen atoms in the carbon chain substituted by fluorine atoms. PFASs exhibit developmental toxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, immunotoxicity, and hormone toxicity. PFASs are used in the production of disposable food packages, aircraft and automobile devices, cooking utensils, outdoor gear, furniture and carpets, aqueous film forming foam (AFFF), cables and wires, electronics, and semiconductors. This study aimed to determine the association between crustacean consumption and serum PFASs.
Methods Adult participants (2,993) aged ≥ 19 years were extracted from the 4th cycle data of the Korean National Environmental Health Survey (KoNEHS). Based on the 50th percentile concentrations of serum PFASs, participants were divided into the low-concentration group (LC) and the high-concentration group (HC). General characteristics, dietary factors, coated product usage, and personal care product usage, an independent t-test and χ2 test were analyzed. The odds ratio (OR) of serum PFAS concentration against crustacean consumption was estimated via logistic regression analysis adjusting for general characteristics, dietary factors, coated product usage, and personal care product usage.
Results The OR for the HC of serum PFASs was higher in individuals with ≥once a week crustacean consumption than in those with < once a week crustacean consumption. Estimated ORs were perfluorohexanesulfonic acid 2.15 (95% confidence interval [CI]: 1.53–3.02), perfluorononanoic acid (PFNA) 1.23 (95% CI: 1.07–1.41), and perfluorodecanoic acid (PFDeA) 1.42 (95% CI: 1.17–1.74) in males, and perfluorooctanoic acid 1.48 (95% CI: 1.19–1.84), perfluorooctanesulfonic acid 1.39 (95% CI: 1.27–1.52), PFNA 1.70 (95% CI: 1.29–2.26) and PFDeA 1.43 (95% CI: 1.32–1.54) in females.
Conclusions This study revealed the association between the crustacean consumption and concentrations of serum PFASs in general Korean population.
- 제4기(2018-2020) 국민환경보건 기초조사 자료를 이용한 갑각률 섭취와 혈청 괍불화화합물(PFAS)과의 관계
목적
과불화화합물은 탄소 사슬에 결합 되어 있는 수소 원자가 불소 원자로 대체된 비방향족 유기 화합물이다. PFAS 는 발달 독성, 발암성, 간 독성, 생식 독성, 면역 독성, 신경 독성 및 호르몬 독성 등을 가진다. PFAS는 일회용 식품 포장, 항공, 자동차, 조리기구, 아웃도어 용품, 가구 및 카펫, 수성막포, 케이블 및 배선, 전자 및 반도체 생산에 사용된다. 본 연구에서는 국가를 대표하는 조사인 한국 국민환경보건 기초조사(KoNEHS) 4주기의 데이터를 사용하여 갑각류 섭취와 혈청 PFAS노출과의 연관성을 확인하려고 한다.
방법
KoNEHS 4주기의 데이터에서 19세 이상 성인 2,993명의 참가자를 분석하였다. 혈청 PFAS 의 50번째 백분위 수 농도를 기준으로 저농도군과 고농도군으로 나누었다. 연구대상의 혈청 PFAS 농도와 일반적 특성, 식이요인, 코팅용품 사용, 미용제품 사용간의 분포 및 평균을 비교하기 위하여 독립 t-검정과 χ2 테스트를 실시하였다. 갑각류 섭취에 대한 혈청 PFAS의 승산비는 일반적 특성, 식이요인, 코팅용품 사용, 미용제품 사용을 보정한 후 로지스틱 회귀분석을 사용하여 계산하였다.
결과
본 연구에서는 갑각류 주1회이상 섭취군은 주1회미만 섭취군에 비해 혈청 PFAS 고농도군에 속할 OR 값이 증가하였다. 남성에서는 PFHxS 2.15(95% confidence interval [CI]; 1.53-3.02), PFNA 1.23(95% CI; 1.07-1.41), PFDeA 1.42(95% CI; 1.17-1.74), 여성에서는 PFOA 1.48(95% CI; 1.19-1.84), PFOS 1.39(95% CI; 1.27-1.52), PFNA 1.70(95% CI; 1.29-2.26), PFDeA 1.43(95% CI; 1.32-1.54) 이었다.
결론
갑각류 섭취 횟수가 많을수록 혈청 PFAS (PFOA, PFOS, PFHxS, PFNA, PFDeA) 농도가 증가하였다. -
Citations
Citations to this article as recorded by
- Environment-wide association study of five per- and polyfluoroalkyl substance (PFASs) exposure pathways in Korean adolescents from the Korean National Environmental Health Survey (2018–2020)
Soonsu Shin, Dajeong Ham, Sanghyuk Bae
Chemosphere.2025; 373: 144161. CrossRef - Environmental disease monitoring by regional Environmental Health
Centers in Korea: a narrative review
Myung-Sook Park, Hwan-Cheol Kim, Woo Jin Kim, Yun-Chul Hong, Won-Jun Choi, Seock-Yeon Hwang, Jiho Lee, Young-Seoub Hong, Yong-Dae Kim, Seong-Chul Hong, Joo Hyun Sung, Inchul Jeong, Kwan Lee, Won-Ju Park, Hyun-Joo Bae, Seong-Yong Yoon, Cheolmin Lee, Kyoung
The Ewha Medical Journal.2025;[Epub] CrossRef - Presence of per- and poly-fluoroalkyl substances (PFAS) in brain samples of marine mammals from the St. Lawrence Estuary and Gulf, Canada
Nejumal Kannankeril Khalid, Amira Aker, Stéphane Lair, Sébastien Sauvé
Environmental Science: Advances.2025; 4(10): 1599. CrossRef - Association between exposure to VOCs mixture and impaired renal function in Korean adults
Seong-Uk Baek, Jin-Ha Yoon
American Journal of Epidemiology.2025;[Epub] CrossRef - The Exposure Status of Environmental Chemicals in South Korea: The Korean National Environmental Health Survey 2018–2020
Sooyeon Hong, Ok-Jin Kim, Sun Kyoung Jung, Hye Li Jeon, Suejin Kim, Jihyon Kil
Toxics.2024; 12(11): 829. CrossRef
- Environment-wide association study of five per- and polyfluoroalkyl substance (PFASs) exposure pathways in Korean adolescents from the Korean National Environmental Health Survey (2018–2020)
- 3,548 View
- 223 Download
- 4 Web of Science
- 5 Crossref
Original Article
- The association of perfluoroalkyl substances (PFAS) exposure and kidney function in Korean adolescents using data from Korean National Environmental Health Survey (KoNEHS) cycle 4 (2018–2020): a cross-sectional study
- Jisuk Yun, Eun-Chul Jang, Soon-Chan Kwon, Young-Sun Min, Yong-Jin Lee
- Ann Occup Environ Med 2023;35:e5. Published online March 15, 2023
- DOI: https://doi.org/10.35371/aoem.2023.35.e5
-
Abstract
Abstract in Korean
PDF
Background Perfluoroalkyl substances (PFAS) are chemicals widely used in various products in everyday life. Due to its unique strong binding force, the half-life of PFAS is very long, so bioaccumulation and toxicity to the human body are long-standing concerns. In particular, effects on kidney function have recently emerged and there are no studies on the effect of PFAS on kidney function through epidemiological investigations in Korea. From 2018 to 2020, the Korean National Environmental Health Survey (KoNEHS) cycle 4, conducted an epidemiological investigation on the blood concentration of PFAS for the first time in Korea. Based on this data, the relationship between PFAS blood concentration and kidney function was analyzed for adolescents.
Methods We investigated 5 types of PFAS and their total blood concentration in 811 middle and high school students, living in Korea and included in KoNEHS cycle 4, and tried to find changes in kidney function in relation to PFAS concentration. After dividing the concentration of each of the 5 PFAS and the total concentration into quartiles, multivariable linear regression was performed to assess the correlation with kidney function. The bedside Schwartz equation was used as an indicator of kidney function.
Results As a result of multivariable linear regression, when observing a change in kidney function according to the increase in the concentration of each of the 5 PFAS and their total, a significant decrease in kidney function was confirmed in some or all quartiles.
Conclusions In this cross-sectional study of Korean adolescents based on KoNEHS data, a negative correlation between serum PFAS concentration and kidney function was found. A well-designed longitudinal study and continuous follow-up are necessary.
- 제 4기 국민환경보건 기초조사(2018-2020) 자료를 바탕으로 한 대한민국 청소년의 과불화 화합물 노출과 신장기능과의 상관관계 연구
목적
과불화 화합물은 일상생활에서 다양한 제품에 널리 쓰이는 화학물질이다. 특유의 강한 결합력으로 인한 반감기가 매우 길기 때문에 이로 인한 생물농축과 인체에 끼치는 독성작용은 오랫동안 큰 관심사이다. 최근에는 특히 신기능에 미치는 영향이 주목받고 있으나 국내에서는 대규모 역학조사를 통한 PFAS가 신기능에 미치는 영향에 대한 조사가 전무한 실정이다. 2018년부터 2020년까지 실시된 국민환경보건 기초조사는 국내 최초로 과불화 화합물의 혈중농도에 대한 대규모 역학조사를 실시했다. 이 자료를 바탕으로 국내 최초로 청소년을 대상으로 하여 과불화 화합물의 혈중농도와 신장기능의 관계를 분석하였다.
방법
제 4기 국민환경보건 기초조사에 포함된 국내에 거주하는 중, 고등학생 828명을 대상으로 5종의 과불화 화합물의 혈중 농도를 조사하고 농도에 따른 신장기능의 변화를 알아보고자 하였다. 5종의 과불화 화합물 각각의 농도와 총 합의 농도를 사분위수로 나눈 후 다중선형회귀분석을 실시하여 신기능과의 상관관계를 분석하였다.
결과
다중선형회귀분석 결과 5종의 과불화 화합물 각각의 농도와 총 합의 농도 증가에 따라 일부 또는 전체 사분위수에서 통계적으로 유의한 신장기능의 감소가 확인되었다.
결론
제 4기 국민환경보건 기초조사 자료를 바탕으로 한국 청소년을 대상으로 한 이번 단면연구에서는 혈중 과불화 화합물의 농도와 신기능 사이에 음의 상관관계가 있음을 발견하였다. 잘 설계된 종단연구와 지속적인 추적관찰이 필요하다. -
Citations
Citations to this article as recorded by- Perfluorooctanoic acid induced lung toxicity via TGF-β1/Smad pathway, crosstalk between airway hyperresponsiveness and fibrosis: withdrawal impact
Arwa A. Elsheikh, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Noha Ali Abd-Almotaleb, Eman El-Sayed Khayal
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