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2 "Population-based study"
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Original Article
Association between urinary bisphenol levels and metabolic syndrome in Korean adults: a cross-sectional study using the fourth Korean National Environmental Health Survey
Chang Ho Jae, Young Hoo Shin, Chang Ho Chae, Chan Woo Kim, Hyoung Ouk Park, Yong Tae Park, Dae Yeon Kang
Ann Occup Environ Med 2026;38:e36.   Published online July 27, 2026
DOI: https://doi.org/10.35371/aoem.2026.38.e36
AbstractAbstract AbstractAbstract in Korean PDF
Background
Bisphenols are representative endocrine-disrupting chemicals and have shown an association with metabolic disorders. Although the use of alternative bisphenols such as bisphenol F (BPF) and bisphenol S (BPS) has been increasing while that of bisphenol A (BPA) has been declining, limited population-based studies exist in Korea examining the association between these substances and metabolic syndrome (MetS). Therefore, this study aimed to evaluate the association of urinary BPA, BPF, and BPS concentrations with MetS in South Korean adults using data from the fourth Korean National Environmental Health Survey (KoNEHS).
Methods
This study included 2,639 participants from the 2018–2019 KoNEHS. MetS was defined based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria. The fasting blood glucose criterion was replaced with glycated hemoglobin (HbA1c) (≥5.7% or medication use). Urinary BPA, BPF, and BPS concentrations were categorized into tertiles per substance. Weighted binary logistic regression analysis accounting for the complex sampling design was performed to calculate odds ratio (OR) and 95% confidence interval (CI).
Results
In the final adjusted model, urinary BPF concentration demonstrated a significant positive association with MetS, with ORs of 1.320 (95% CI: 1.029–1.693) for T2 and 1.452 (95% CI: 1.122–1.878) for T3. Urinary BPS concentration demonstrated a significant association only in the highest tertile, with an OR of 1.476 (95% CI: 1.067–2.043) for T3. Conversely, urinary BPA concentration did not show a significant association with MetS.
Conclusions
In this study, urinary BPF and BPS concentrations in the general Korean adult population showed a significant positive association with MetS. The study findings may provide a baseline for expanding our understanding of the effects of bisphenols on health. Future long-term, prospective studies involving the general population remain necessary.
대한민국 성인에서 요중 비스페놀 수치와 대사증후군과의 연관성: 제 4기 국민환경보건 기초조사를 이용한 단면연구
목적
비스페놀은 대표적인 내분비계 교란 화학물질로, 대사 이상과의 관련성이 제기되어 왔다. 특히 최근에는 bisphenol A (BPA)의 사용 감소와 함께 bisphenol F (BPF), bisphenol S (BPS) 등의 대체 비스페놀 사용이 증가하고 있으나, 이들 물질과 대사증후군(metabolic syndrome, MetS) 간의 연관성에 대한 국내 일반 인구 기반 연구는 부족하다. 이에 본 연구는 제4기 국민환경보건 기초조사(Korean National Environmental Health Survey, KoNEHS) 자료를 이용하여 대한민국 성인에서 요중 BPA, BPF, BPS 농도와 MetS 간의 연관성을 평가하고자 하였다.
방법
본 연구는 KoNEHS 참여자 중 2018-2019년 대상자 2,639명을 대상으로 연구를 진행하였다. MetS는 수정된 National Cholesterol Education Program Adult Treatment Panel III 기준을 적용하여 정의하였고, 공복혈당 항목은 HbA1c (≥5.7% 또는 약물 복용)로 대체하였다. 요중 BPA, BPF, BPS 농도는 각 물질별 삼분위수로 범주화하였다. 복합표본설계를 반영한 이분형 로지스틱 회귀분석을 시행하여 교차비(odds ratio, OR)와 95% 신뢰구간(confidence interval, CI)을 산출하였다.
결과
최종 보정 모델에서 요중 BPF 농도는 MetS와 유의한 양의 연관성을 보였으며, OR은 T2에서 1.320 (95% CI: 1.029–1.693), T3에서 1.452 (95% CI: 1.122–1.878)였다. 요중 BPS 농도는 최고 삼분위수에서만 유의한 연관성을 보였으며, T3의 OR은 1.476 (95% CI: 1.067–2.043)이었다. 반면 요중 BPA 농도는 MetS와 유의한 연관성을 보이지 않았다.
결론
본 연구에서는 대한민국 성인 일반 인구에서 요중 BPF와 BPS 농도는 MetS와 유의한 양의 연관성을 보였다. 본 연구 결과는 bisphenol의 건강 영향에 대한 이해를 넓히는 기초 자료로 활용될 수 있으며, 향후 일반 인구를 대상으로 한 장기적이고 전향적인 연구가 필요하다.
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Research Article
Factors increasing the risk for psychosocial stress among Korean adults living in rural areas: using generalized estimating equations and mixed models
Ju-Hyun Nam, Myeong-Seob Lim, Hyun-Kyeong Choi, Jae-Yeop Kim, Sung-Kyeong Kim, Sung-Soo Oh, Sang-Baek Koh, Hee-Tae Kang
Ann Occup Environ Med 2017;29:53.   Published online October 31, 2017
DOI: https://doi.org/10.1186/s40557-017-0209-5
AbstractAbstract PDF
Background

This study was conducted to analyze the distribution of the psychosocial well-being index among adults living in two rural communities in Korea and to examine its correlation with lifestyle variables such as sleep duration, regular exercise, and sedentary time.

Methods

Using the cohort data of the Atherosclerosis Risk of a Rural Area Korean General Population, this study examined 3631 participants living in Wonju and Pyeongchang in Gangwon Province; their preliminary data were established from 2005 to 2007 while their follow-up data were collected 3 years later. This study investigated demographic characteristics, lifestyle habits, disease history, Psychosocial Well-being Index-Short Form (PWI-SF) scores, sleep duration, regular exercise, and sedentary time during work. Using repeated measures ANOVA, this study examined how the variables and PWI-SF scores changed over the course of 3 years and identified the correlation between them based on mixed model analysis. Afterwards, using the generalized estimation equation, this study identified each variable’s risk towards the PWI-SF high-risk group and performed a stratified analysis by occupation after dividing the participants into farmers and non-farmers.

Results

The PWI-SF high-risk group was found to be 18.9% of the participants from preliminary data and 15.5% from follow-up data. The odds ratio towards the PWI-SF high-risk group was 1.503 (95% CI 1.241–1.821) in the short sleep duration group and 1.327 (95% CI 1.136–1.550) in the non-regular exercise group. A stratified analysis by occupation showed that middle and long sedentary time in the white-collar group increased the risk toward the PWI-SF high-risk group.

Conclusions

Short sleep duration, no regular exercise, and long sedentary time in the white-collar group were identified as risk factors toward the PWI-SF high-risk group in the rural communities, and policy interventions are needed to address this issue.


Citations

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